HoVerNet

tiatoolbox . models . architecture . hovernet . HoVerNet

class HoVerNet(num_input_channels=3, num_types=None, mode='original', nuc_type_dict=None)

Initialise HoVerNet [1].

The tiatoolbox models should produce the following results:

HoVerNet segmentation performance on the CoNSeP dataset [1]

Model name	Data set	DICE	AJI	DQ	SQ	PQ
hovernet-original-consep	CoNSeP	0.85	0.57	0.70	0.78	0.55

HoVerNet segmentation performance on the Kumar dataset [2]

Model name	Data set	DICE	AJI	DQ	SQ	PQ
hovernet-original-kumar	Kumar	0.83	0.62	0.77	0.77	0.60

Parameters:

• num_input_channels (int) – Number of channels in input.

• num_types (int) – Number of nuclei types within the predictions. Once defined, a branch dedicated for typing is created. By default, no typing (num_types=None) is used.

• mode (str) – To use architecture defined in as in original paper (original) or the one used in PanNuke paper (fast).

• nuc_type_dict (dict | None)

References

[1] Graham, Simon, et al. “HoVerNet: Simultaneous segmentation and classification of nuclei in multi-tissue histology images.” Medical Image Analysis 58 (2019): 101563.

[2] Kumar, Neeraj, et al. “A dataset and a technique for generalized nuclear segmentation for computational pathology.” IEEE transactions on medical imaging 36.7 (2017): 1550-1560.

Initialize HoVerNet.

Methods

forward	Logic for using layers defined in init.
get_instance_info	To collect instance information and store it within a dictionary.
infer_batch	Run inference on an input batch.
postproc	Post-processing script for image tiles.

Attributes

training

forward(input_tensor)

Logic for using layers defined in init.

This method defines how layers are used in forward operation.

Parameters:

• input_tensor (torch.Tensor) – Input images, the tensor is in the shape of NCHW.

• self (HoVerNet)

Returns:

A dictionary containing the inference output. The expected format os {decoder_name: prediction}.

Return type:

dict

static get_instance_info(pred_inst, pred_type=None)

To collect instance information and store it within a dictionary.

Parameters:

• pred_inst (numpy.ndarray) – An image of shape (height, width) which contains the probabilities of a pixel being a nuclei.

• pred_type (numpy.ndarray) – An image of shape (height, width, 1) which contains the probabilities of a pixel being a certain type of nuclei.

Returns:

A dictionary containing a mapping of each instance within pred_inst instance information. It has the following form:

{
    0: {  # Instance ID
        "box": [
            x_min,
            y_min,
            x_max,
            y_max,
        ],
        "centroid": [x, y],
        "contour": [
            [x, y],
            ...
        ],
        "type": integer,
        "prob": float,
    },
    ...
}

where the instance ID is an integer corresponding to the instance at the same pixel value within pred_inst.

Return type:

dict

static infer_batch(model, batch_data, *, on_gpu)

Run inference on an input batch.

This contains logic for forward operation as well as batch i/o aggregation.

Parameters:

• model (nn.Module) – PyTorch defined model.

• batch_data (ndarray) – A batch of data generated by torch.utils.data.DataLoader.

• on_gpu (bool) – Whether to run inference on a GPU.

Returns:

Output from each head. Each head is expected to contain N predictions for N input patches. There are two cases, one with 2 heads (Nuclei Pixels np and Hover hv) or with 2 heads (np, hv, and Nuclei Types tp).

Return type:

tuple

static postproc(raw_maps)

Post-processing script for image tiles.

Parameters:

raw_maps (list(numpy.ndarray)) – A list of prediction outputs of each head and assumed to be in the order of [np, hv, tp] (match with the output of infer_batch).

Returns:

• numpy.ndarray - Instance map:

  Pixel-wise nuclear instance segmentation prediction.

• dict - Instance dictionary:

  A dictionary containing a mapping of each instance within inst_map instance information. It has the following form:

  {
      0: {  # Instance ID
          "box": [
              x_min,
              y_min,
              x_max,
              y_max,
          ],
          "centroid": [x, y],
          "contour": [
              [x, y],
              ...
          ],
          "type": 1,
          "prob": 0.95,
      },
      ...
  }
  

  where the instance ID is an integer corresponding to the instance at the same pixel location within the returned instance map.

Return type:

tuple

Examples

>>> from tiatoolbox.models.architecture.hovernet import HoVerNet
>>> import torch
>>> import numpy as np
>>> batch = torch.from_numpy(image_patch)[None]
>>> # image_patch is a 256x256x3 numpy array
>>> weights_path = "A/weights.pth"
>>> pretrained = torch.load(weights_path)
>>> model = HoVerNet(num_types=6, mode="fast")
>>> model.load_state_dict(pretrained)
>>> output = model.infer_batch(model, batch, on_gpu=False)
>>> output = [v[0] for v in output]
>>> output = model.postproc(output)